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MicroRNA profiling of human multiple myeloma cells and monoclonal gammopathy of undetermined significance (MGUS) cells

ABSTRACT: MicroRNA expression profiles for human Multilple Myeloma and MGUS (monoclonal gammopathy of undetermined significance) were examined to investigate the miRNA involvement in the development of this neoplasia.

INSTRUMENT(S): Scanning hardware

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Cristian Taccioli

PROVIDER: E-TABM-508 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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MicroRNAs regulate critical genes associated with multiple myeloma pathogenesis.

Pichiorri Flavia F Suh Sung-Suk SS Ladetto Marco M Kuehl Michael M Palumbo Tiziana T Drandi Daniela D Taccioli Cristian C Zanesi Nicola N Alder Hansjuerg H Hagan John P JP Munker Reinhold R Volinia Stefano S Boccadoro Mario M Garzon Ramiro R Palumbo Antonio A Aqeilan Rami I RI Croce Carlo M CM

Proceedings of the National Academy of Sciences of the United States of America 20080826 35

Progress in understanding the biology of multiple myeloma (MM), a plasma cell malignancy, has been slow. The discovery of microRNAs (miRNAs), a class of small noncoding RNAs targeting multiple mRNAs, has revealed a new level of gene expression regulation. To determine whether miRNAs play a role in the malignant transformation of plasma cells (PCs), we have used both miRNA microarrays and quantitative real time PCR to profile miRNA expression in MM-derived cell lines (n = 49) and CD138+ bone marr ...[more]

PMID: 18728182

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