Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Bruz Marzolf
PROVIDER: E-MEXP-730 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Gilchrist Mark M Thorsson Vesteinn V Li Bin B Rust Alistair G AG Korb Martin M Roach Jared C JC Kennedy Kathleen K Hai Tsonwin T Bolouri Hamid H Aderem Alan A
Nature 20060501 7090
The innate immune system is absolutely required for host defence, but, uncontrolled, it leads to inflammatory disease. This control is mediated, in part, by cytokines that are secreted by macrophages. Immune regulation is extraordinarily complex, and can be best investigated with systems approaches (that is, using computational tools to predict regulatory networks arising from global, high-throughput data sets). Here we use cluster analysis of a comprehensive set of transcriptomic data derived f ...[more]