Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of wild type and orb2 knock-out Drosophila melanogaster


ABSTRACT: Examination of developmental impact of orb2 knockout

ORGANISM(S): Drosophila melanogaster

SUBMITTER: Ariel Paulson 

PROVIDER: E-TABM-527 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Drosophila Orb2 targets genes involved in neuronal growth, synapse formation, and protein turnover.

Mastushita-Sakai Tomoko T   White-Grindley Erica E   Samuelson Jessica J   Seidel Chris C   Si Kausik K  

Proceedings of the National Academy of Sciences of the United States of America 20100614 26


In the study of long-term memory, how memory persists is a fundamental and unresolved question. What are the molecular components of the long-lasting memory trace? Previous studies in Aplysia and Drosophila have found that a neuronal variant of a RNA-binding protein with a self-perpetuating prion-like property, cytoplasmic polyadenylation element binding protein, is required for the persistence of long-term synaptic facilitation in the snail and long-term memory in the fly. In this study, we hav  ...[more]

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