Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Sheng Xia
PROVIDER: E-TABM-411 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Xia Sheng S Li Xiaogang X Johnson Teri T Seidel Chris C Wallace Darren P DP Li Rong R
Development (Cambridge, England) 20100224 7
Polycystin 1 and polycystin 2 are large transmembrane proteins, which, when mutated, cause autosomal dominant polycystic kidney disease (ADPKD), a highly prevalent human genetic disease. The polycystins are thought to form a receptor-calcium channel complex in the plasma membrane of renal epithelial cells and elicit a calcium influx in response to mechanical stimulation, such as fluid flow across the apical surface of renal epithelial cells. The functional role of the polycystins in mechanosensa ...[more]