Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of mouse wild type and pkd1-/- kidney epithelial cells with and without fluid flow


ABSTRACT: Examining GE profiles in kidney epithelial cells with & without fluid flow

ORGANISM(S): Mus musculus

SUBMITTER: Sheng Xia 

PROVIDER: E-TABM-411 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Polycystin-dependent fluid flow sensing targets histone deacetylase 5 to prevent the development of renal cysts.

Xia Sheng S   Li Xiaogang X   Johnson Teri T   Seidel Chris C   Wallace Darren P DP   Li Rong R  

Development (Cambridge, England) 20100224 7


Polycystin 1 and polycystin 2 are large transmembrane proteins, which, when mutated, cause autosomal dominant polycystic kidney disease (ADPKD), a highly prevalent human genetic disease. The polycystins are thought to form a receptor-calcium channel complex in the plasma membrane of renal epithelial cells and elicit a calcium influx in response to mechanical stimulation, such as fluid flow across the apical surface of renal epithelial cells. The functional role of the polycystins in mechanosensa  ...[more]

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