Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Ariel Paulson
PROVIDER: E-TABM-404 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Haug Jeffrey S JS He Xi C XC Grindley Justin C JC Wunderlich Joshua P JP Gaudenz Karin K Ross Jason T JT Paulson Ariel A Wagner Kathryn P KP Xie Yucai Y Zhu Ruihong R Yin Tong T Perry John M JM Hembree Mark J MJ Redenbaugh Erin P EP Radice Glenn L GL Seidel Christopher C Li Linheng L
Cell stem cell 20080401 4
Osteoblasts expressing the homophilic adhesion molecule N-cadherin form a hematopoietic stem cell (HSC) niche. Therefore, we examined how N-cadherin expression in HSCs relates to their function. We found that bone marrow (BM) cells highly expressing N-cadherin (N-cadherin(hi)) are not stem cells, being largely devoid of a Lineage(-)Sca1(+)cKit(+) population and unable to reconstitute hematopoietic lineages in irradiated recipient mice. Instead, long-term HSCs form distinct populations expressing ...[more]