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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of human macrophages from Crohns disease patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli;

ABSTRACT: Comparison of gene expression in macrophages from Crohn's disease patients or healthy control individuals, either unstimulated or stimulated with heat killed E. coli

ORGANISM(S): Homo sapiens

SUBMITTER: Ann Walker

PROVIDER: E-TABM-733 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Disordered macrophage cytokine secretion underlies impaired acute inflammation and bacterial clearance in Crohn's disease.

Smith Andrew M AM Rahman Farooq Z FZ Hayee Bu'Hussain B Graham Simon J SJ Marks Daniel J B DJ Sewell Gavin W GW Palmer Christine D CD Wilde Jonathan J Foxwell Brian M J BM Gloger Israel S IS Sweeting Trevor T Marsh Mark M Walker Ann P AP Bloom Stuart L SL Segal Anthony W AW

The Journal of experimental medicine 20090803 9

The cause of Crohn's disease (CD) remains poorly understood. Counterintuitively, these patients possess an impaired acute inflammatory response, which could result in delayed clearance of bacteria penetrating the lining of the bowel and predispose to granuloma formation and chronicity. We tested this hypothesis in human subjects by monitoring responses to killed Escherichia coli injected subcutaneously into the forearm. Accumulation of (111)In-labeled neutrophils at these sites and clearance of ...[more]

PMID: 19652016

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