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Comparative genomic hybridization of human nasal NK/T-cell Lymphoma (8 tumor samples, 2 cell lines)

ABSTRACT: A ï¾Cartes dï¾Identite des Tumeursï¾ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net ) | Human genome-wide CIT-aCGH-V6-4.4K : 8 NKTCL biopsies, 2 NKTCL cell lines. Biopsies and cell lines of NK/T-cell lymphoma, nasal-type (NKTCL) were subject to combined gene expression profiling (see E-TABM-702) and array-based comparative genomic hybridization analyses. | Submitter : Aurelien de Reynies | Project leader : Philippe Gaulard

ORGANISM(S): Homo sapiens

DISEASE(S): extranodal NK/T-Cell Lymphoma derived cell line

SUBMITTER: Aurelien de Reynies

PROVIDER: E-TABM-791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type.

Huang Yenlin Y de Reyniès Aurélien A de Leval Laurence L Ghazi Bouchra B Martin-Garcia Nadine N Travert Marion M Bosq Jacques J Brière Josette J Petit Barbara B Thomas Emilie E Coppo Paul P Marafioti Teresa T Emile Jean-François JF Delfau-Larue Marie-Hélène MH Schmitt Christian C Gaulard Philippe P

Blood 20091130 6

Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses. Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-cell and cytotoxic molecules, especially granzyme H. Compared with normal NKcells, tumors were closer to activated than resting cells and overexpressed several genes related to vascular biology, Epstei ...[more]

PMID: 19965620

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