Browse
Submit Data
Databases
API
Help

Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Comparative genomic hybridization of human nasal NK/T-cell Lymphoma (8 tumor samples, 2 cell lines)

ABSTRACT: A ï¾Cartes dï¾Identite des Tumeursï¾ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net ) | Human genome-wide CIT-aCGH-V6-4.4K : 8 NKTCL biopsies, 2 NKTCL cell lines. Biopsies and cell lines of NK/T-cell lymphoma, nasal-type (NKTCL) were subject to combined gene expression profiling (see E-TABM-702) and array-based comparative genomic hybridization analyses. | Submitter : Aurelien de Reynies | Project leader : Philippe Gaulard

ORGANISM(S): Homo sapiens

DISEASE(S): extranodal NK/T-Cell Lymphoma derived cell line

SUBMITTER: Aurelien de Reynies

PROVIDER: E-TABM-791 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

ACCESS DATA

Json Xml

Publications

Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal type.

Huang Yenlin Y de Reyniès Aurélien A de Leval Laurence L Ghazi Bouchra B Martin-Garcia Nadine N Travert Marion M Bosq Jacques J Brière Josette J Petit Barbara B Thomas Emilie E Coppo Paul P Marafioti Teresa T Emile Jean-François JF Delfau-Larue Marie-Hélène MH Schmitt Christian C Gaulard Philippe P

Blood 20091130 6

Biopsies and cell lines of natural killer/T-cell lymphoma, nasal type (NKTCL) were subject to combined gene expression profiling and array-based comparative genomic hybridization analyses. Compared with peripheral T-cell lymphoma, not otherwise specified, NKTCL had greater transcript levels for NK-cell and cytotoxic molecules, especially granzyme H. Compared with normal NKcells, tumors were closer to activated than resting cells and overexpressed several genes related to vascular biology, Epstei ...[more]

PMID: 19965620

Similar Datasets

Comparative genomic hybridization of human glioblastomas

Project description:A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net ) | Human genome-wide CIT-aCGH-V6-4.4K : 67 glioblastomas | Submitter : Aurelien de Reynies <reyniesa@ligue-cancer.fr> | Project leader : Francois Berger <fberger@ujf-grenoble.fr>

2010-06-30 | E-TABM-897 | biostudies-arrayexpress

Expression and CGHarray profiling of Hepatosplenic T-cell Lymphomas (10 tumor samples)

Project description:A Cartes dIdentite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 10 HSTL samples including biopsies (n=6), sorted tumor cells (n=3), cell line (n=1) | Agilent SurePrint G3 Human CGH Microarray 4x180K Arrays : 7 HSTL samples including biopsies (n=5), sorted tumor cells (n=1), cell line (n=1) | Submitter : Aurelien de Reynies <reyniesa@ligue-cancer.fr> | Project leader : Philippe Gaulard <philippe.gaulard@hmn.aphp.fr> The E-MTAB-638.additional.1.zip archive contains the CGH processed data file with additional chromosome coordiantes.

2011-09-30 | E-MTAB-638 | biostudies-arrayexpress

Expression and CGH array profiling of ductal carcinoma (135 tumor samples)

Project description:A Cartes d'Identité des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | Affymetrix HG-U133 Plus 2.0 : 46 samples| Agilent SurePrint G3 Human CGH Microarray 4x180K Arrays : 135 samples| To explore the prognostic value of genomic alterations present in primary tumours we perfom a comparative genomic hybridization study on BAC arrays for a panel of breast carcinoma from 45 patients with metastatic relapse and 95 others one, matched for age and axillary node involvement, without any recurrence after 11 years of follow up. Array CGH data was used in establishing a two parameters index representative first of the global level of aneusomy by chromosomal arm and second of the number of breackpoints throughout the genome. Submitter : Nabila Elarouci <elaroucin@ligue-cancer.fr> | Project leader : Michel Longy <longy@bergonie.org>

2012-02-01 | E-MTAB-748 | biostudies-arrayexpress

Gene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics [CGH]

Project description:From a clinical and molecular perspective, colon cancer (CC) is a heterogeneous disease but to date no classification based on high-density transcriptome data has been established. The aim of this study was to build up a robust molecular classification ofÂ mRNA expression profiles (Affymetrix U133Plus2) ofÂ a large series of 443 CC and to validate it on an independent serie of 123 CC and 906 public dataset.Â We identified and validated six molecular subtypes in this large cohort as a combination of multiple molecular processes that complement current disease stratification based on clinicopathological variables and molecular markers. The biological relevance of these subtypes was consolidated by significant differences in survival. These insights open new perspectives for improving prognostic models and targeted therapies. Among a large series of colon cancers collected for the Cartes d'IdentitÃ© des Tumeurs (CIT) program from the French Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net), 566 were analyzed for mRNA expression profiles using Affymetrix U133plus2 chip and, among theses, 463 could also be analyzed for DNA alteration profiles using the CGH Array (Â CIT-CGHarray V6). The 566 tumors was divided into a discovery dataset of 443 CC and a validation dataset of 123 CC.

2013-05-22 | E-GEOD-40966 | biostudies-arrayexpress

Comparative genomic hybridization of 84 head and neck squamous cell carcinoma

Project description:A ﾑCartes dﾒIdentite des Tumeursﾒ (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net ) | Human genome-wide CIT-aCGH-V7-4.7K : 84 HNSCC | Submitter : Aurelien de Reynies <reyniesa@ligue-cancer.fr> | Project leader : Bohdan Wazylyk <boh@igbmc.fr>

2010-05-15 | E-TABM-995 | biostudies-arrayexpress

CGHarray profiling of adrenocortical tumors (ACTs)

Project description:A Cartes dM-^RIdentite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | IntegraChipTM BAC pangenomic arrays (IntegraGen, Evry, France) : 59 ACTs samples including adrenocortical carcinomas (n=21) and adenomas (n=38) | Submitter : Olivia Barreau <olivia.barreau@inserm.fr> | Project leader : Jerome Bertherat <jerome.bertherat@inserm.fr>.

2011-04-18 | E-MTAB-659 | biostudies-arrayexpress

Gene expression Classification of Colon Cancer defines six molecular subtypes with distinct clinical, molecular and survival characteristics

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2013-05-22 | E-GEOD-40967 | biostudies-arrayexpress

Transcription profiling of human ductal and lobular breast cancers with familial or Cowden disease history.

Project description:A Cartes d'Identite des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net) | 74 samples on Affymetrix HG-U133 Plus 2.0 GeneChips arrays for 74 patients. 5 samples on CGH CIT v7 | Breast carcinoma is the main malignant tumor occurring in patients with Cowden disease, a cancer prone syndrome caused by germline mutation of the tumor suppressor gene PTEN. To better understand this disease, we have performed a transcriptomic study of three Cowden disease breast carcinomas included in a panel of 74 familial breast cancers. Unsupervised clustering of these 74 tumors followed the intrinsic gene classification of breast cancer except for a group of five tumors that included the three Cowden tumors. The gene expression profile of the Cowden tumors shows considerable overlap with that of a breast cancer subgroup known as molecular apocrine breast carcinoma, which is suspected to have increased androgenic signaling and shows frequent ERBB2 amplification. A histological and immunohistochemical study performed on 13 additional cases of Cowden disease breast carcinomas, for which RNA was not available, showed that they have apocrine histological features and express GGT1, a marker of molecular apocrine breast carcinoma. These data suggest that activation of the ERBB2-PI3K-AKT pathway by loss of PTEN at early stages of tumorigenesis promotes the formation of breast tumors with apocrine features. | Submitter : Renaud Schiappa schiappar@ligue-cancer.net | Project leader : Michel Longy longy@bergonie.org

2010-07-29 | E-TABM-854 | biostudies-arrayexpress

Comparative genomic hybridization of human hepatoblastomas identifies two tumor subclasses resembling distinct phases of liver development

Project description:A "Cartes d'Identite des Tumeurs" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). Hepatoblastoma, the most common pediatric liver cancer, is tightly linked to excessive Wnt/C/B?B=-catenin signaling. Microarray analysis identifitwo tumor subclasses resembling distinct phases of liver development typified by gains of chromosomes 8q and 2p and upregulated Myc signaling.

2008-12-19 | E-MEXP-1852 | biostudies-arrayexpress

Genotyping of Malignant Pleural Mesothelioma primary cell lines by SNP array

Project description:SNP array data from 45 cell lines of Malignant Pleural Mesothelioma were used to explore recurrent copy number alterations. This study was part of Cartes d'Identité des Tumeurs (CIT) project from the french Ligue Nationale Contre le Cancer.

2023-12-31 | GSE197288 | GEO

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data