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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of irradiated human lymphocytes from prostate carcinoma patients following curative radiotherapy to study late radiation toxicity

ABSTRACT: For a case-control study, we selected 54 prostate carcinoma patients with no evidence of disease 2 years after curative

ORGANISM(S): Homo sapiens

SUBMITTER: Jaap Haveman

PROVIDER: E-TABM-90 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity.

Svensson J Peter JP Stalpers Lukas J A LJ Esveldt-van Lange Rebecca E E RE Franken Nicolaas A P NA Haveman Jaap J Klein Binie B Turesson Ingela I Vrieling Harry H Giphart-Gassler Micheline M

PLoS medicine 20061001 10

<h4>Background</h4>Radiation is an effective anti-cancer therapy but leads to severe late radiation toxicity in 5%-10% of patients. Assuming that genetic susceptibility impacts this risk, we hypothesized that the cellular response of normal tissue to X-rays could discriminate patients with and without late radiation toxicity.<h4>Methods and findings</h4>Prostate carcinoma patients without evidence of cancer 2 y after curative radiotherapy were recruited in the study. Blood samples of 21 patients ...[more]

PMID: 17076557

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