Ontology highlight
ABSTRACT:
SUBMITTER: Gonzalez PC
PROVIDER: S-EPMC10096420 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20230401 7
Starting from commercially available ketones, a reproducible and reliable strategy for the synthesis of tetrasubstituted nitroalkenes was successfully developed, using a two-step procedure; the HWE olefination of the ketone to form the corresponding α,β-unsaturated esters is followed by a nitration reaction to introduce the nitro group in the α position of the ester group. The enantioselective organocatalytic reduction of these compounds has also been preliminarily studied, to access the functio ...[more]