A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.
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ABSTRACT:
SUBMITTER: Estep JA
PROVIDER: S-EPMC10119766 | biostudies-literature | 2023 Apr
REPOSITORIES: biostudies-literature
Publications
A luciferase fragment complementation assay to detect focal adhesion kinase (FAK) signaling events.
Estep Jason A JA Sun Lu O LO Riccomagno Martin M MM
Heliyon 20230405 4
Integrin Adhesion Complexes (IACs) serve as links between the cytoskeleton and extracellular environment, acting as mechanosensing and signaling hubs. As such, IACs participate in many aspects of cellular motility, tissue morphogenesis, anchorage-dependent growth and cell survival. Focal Adhesion Kinase (FAK) has emerged as a critical organizer of IAC signaling events due to its early recruitment and diverse substrates, and thus has become a genetic and therapeutic target. Here we present the de ...[more]
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