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Multiple thiol-anchor capped DNA-gold nanoparticle conjugates.

ABSTRACT: We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to stabilize particles >30 nm in diameter, which are essential for many diagnostic applications.

SUBMITTER: Li Z

PROVIDER: S-EPMC101851 | biostudies-literature | 2002 Apr

REPOSITORIES: biostudies-literature

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Multiple thiol-anchor capped DNA-gold nanoparticle conjugates.

Li Zhi Z Jin Rongchao R Mirkin Chad A CA Letsinger Robert L RL

Nucleic acids research 20020401 7

We report the synthesis of a novel trithiol-capped oligodeoxyribonucleotide and gold nanoparticle conjugates prepared from it. These DNA-gold nanoparticle conjugates exhibit substantially higher stability than analogs prepared from monothiol and cyclic disulfide-capped oligodeoxyribonucleotides, but comparable hybridization properties. A quantitative analysis of their stability under a range of conditions is provided. Significantly, this novel trithiol oligodeoxyribonucleotide can be used to sta ...[more]

PMID: 11917016

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