Ontology highlight
ABSTRACT:
SUBMITTER: Niimi A
PROVIDER: S-EPMC10216351 | biostudies-literature | 2023 May
REPOSITORIES: biostudies-literature
Niimi Atsuko A Limsirichaikul Siripan S Kano Keiko K Mizutani Yasuyoshi Y Takeuchi Toshiyuki T Sawangsri Patinya P Tran Dat Quoc DQ Kawamoto Yoshiyuki Y Suzuki Motoshi M
Cancers 20230516 10
CERS6 is associated with metastasis and poor prognosis in non-small cell lung cancer (NSCLC) patients through d18:1/C16:0 ceramide (C16 ceramide)-mediated cell migration, though the detailed mechanism has not been elucidated. In the present study, examinations including co-immunoprecipitation, liquid chromatography, and tandem mass spectrometry analysis were performed to identify a novel binding partner of CERS6. Among the examined candidates, LASP1 was a top-ranked binding partner, with the LIM ...[more]