Ontology highlight
ABSTRACT:
SUBMITTER: Khandazhinskaya A
PROVIDER: S-EPMC9114674 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Frontiers in chemistry 20220504
A new series of flexible 5'-norcarbocyclic aza/deaza-purine nucleoside analogs were synthesized from 6-oxybicyclo[3.1.0.]hex-2-ene and pyrazole-containing fleximer analogs of heterocyclic bases using the Trost procedure. The compounds were evaluated as potential inhibitors of <i>E. coli</i> purine nucleoside phosphorylase. Analog <b>1-3</b> were found to be noncompetitive inhibitors with inhibition constants of 14-24 mM. From the data obtained, it can be assumed that the new 5'-norcarbocyclic nu ...[more]