Ontology highlight
ABSTRACT:
SUBMITTER: Wennerberg E
PROVIDER: S-EPMC7125001 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wennerberg Erik E Spada Sheila S Rudqvist Nils-Petter NP Lhuillier Claire C Gruber Sylvia S Chen Qiuying Q Zhang Fengli F Zhou Xi K XK Gross Steven S SS Formenti Silvia C SC Demaria Sandra S
Cancer immunology research 20200211 4
The ability of focal radiotherapy to promote priming of tumor-specific CD8<sup>+</sup> T cells and increase responses to immunotherapy is dependent on infiltration of the tumor by Batf3-dependent conventional dendritic cell type 1 (cDC1) cells. Such infiltration is driven by radiotherapy-induced IFN type I (IFN-I). Other signals may also modulate cDC1 infiltration of irradiated tumors. Here we found increased expression of adenosine-generating enzymes CD38 and CD73 in irradiated mouse and human ...[more]