THOC2 expression and its impact on 5-fluorouracil resistance in glioblastoma multiforme.
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ABSTRACT:
SUBMITTER: Lee YJ
PROVIDER: S-EPMC10326588 | biostudies-literature | 2023
REPOSITORIES: biostudies-literature
Publications
THOC2 expression and its impact on 5-fluorouracil resistance in glioblastoma multiforme.
Lee Young Jun YJ Jung Jin-Hwa JH Chang Da-Young DY Kim Min Gyeong MG Bashyal Narayan N Hwang Woo Sup WS Woo Hyun Goo HG Paek Sun Ha SH Suh-Kim Haeyoung H Kim Sung-Soo SS
American journal of cancer research 20230615 6
Glioblastoma multiforme (GBM) is a highly aggressive brain tumor with poor prognosis and limited treatment options. While 5-fluorouracil (5-FU) has not been widely employed in GBM therapy, emerging research indicates its potential for effectiveness when combined with advanced drug delivery systems to improve its transport to brain tumors. This study aims to investigate the role of THOC2 expression in 5-FU resistance in GBM cell lines. We evaluated diverse GBM cell lines and primary glioma cells ...[more]
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