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Serinol-Based Versatile Disulfide-Reducing Reagent.

ABSTRACT: Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT.

SUBMITTER: Kushwaha B

PROVIDER: S-EPMC10384529 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Serinol-Based Versatile Disulfide-Reducing Reagent.

Kushwaha Babita B Mthembu Sinenhlanhla N SN Sharma Anamika A Albericio Fernando F de la Torre Beatriz G BG

Molecules (Basel, Switzerland) 20230718 14

Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT. ...[more]

PMID: 37513361

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