Ontology highlight
ABSTRACT:
SUBMITTER: Perl AL
PROVIDER: S-EPMC10404246 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Perl Abbey L AL Koetsier Jennifer L JL Green Kathleen J KJ
Scientific reports 20230805 1
Critical for the maintenance of epidermal integrity and function are attachments between intermediate filaments (IF) and intercellular junctions called desmosomes. The desmosomal cytoplasmic plaque protein desmoplakin (DP) is essential for anchoring IF to the junction. DP-IF interactions are regulated by a phospho-regulatory motif within the DP C-terminus controlling keratinocyte intercellular adhesion. Here we identify the protein phosphatase 2A (PP2A)-B55α holoenzyme as the major serine/threon ...[more]