Ontology highlight
ABSTRACT:
SUBMITTER: Liu S
PROVIDER: S-EPMC10439213 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Nature communications 20230818 1
Prion-like spreading of protein misfolding is a characteristic of neurodegenerative diseases, but the exact mechanisms of intercellular protein aggregate dissemination remain unresolved. Evidence accumulates that endogenous retroviruses, remnants of viral germline infections that are normally epigenetically silenced, become upregulated in neurodegenerative diseases such as amyotrophic lateral sclerosis and tauopathies. Here we uncover that activation of endogenous retroviruses affects prion-like ...[more]