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One-pot, three-component, iron-catalyzed synthesis of benzimidazoles via domino C-N bond formation.

ABSTRACT: An efficient one-pot, three-component process for the synthesis of benzimidazole derivatives using a catalytic amount of Fe(iii) porphyrin has been developed. The reaction proceeds via domino C-N bond formation and cyclization reactions of benzo-1,2-quinone, aldehydes and ammonium acetate as a nitrogen source to selectively produce benzimidazole. A number of benzimidazole derivatives have been synthesized using this method in high yields under mild reaction conditions.

SUBMITTER: Aboonajmi J

PROVIDER: S-EPMC10440634 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature

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One-pot, three-component, iron-catalyzed synthesis of benzimidazoles via domino C-N bond formation.

Aboonajmi Jasem J Mohammadi Masoumeh M Panahi Farhad F Aberi Mahdi M Sharghi Hashem H

RSC advances 20230821 35

An efficient one-pot, three-component process for the synthesis of benzimidazole derivatives using a catalytic amount of Fe(iii) porphyrin has been developed. The reaction proceeds via domino C-N bond formation and cyclization reactions of benzo-1,2-quinone, aldehydes and ammonium acetate as a nitrogen source to selectively produce benzimidazole. A number of benzimidazole derivatives have been synthesized using this method in high yields under mild reaction conditions. ...[more]

PMID: 37608969

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