Ontology highlight
ABSTRACT:
SUBMITTER: Seo T
PROVIDER: S-EPMC10441400 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
bioRxiv : the preprint server for biology 20230810
Cadherin family proteins play a central role in epithelial and endothelial cell-cell adhesion. The dynamic regulation of cell adhesion is achieved in part through endocytic membrane trafficking pathways that modulate cadherin cell surface levels. Here, we define the role for various MARCH family ubiquitin ligases in the regulation of cadherin degradation. We find that MARCH2 selectively downregulates VE-cadherin, resulting in loss of adherens junction proteins at cell borders and a loss of endot ...[more]