Ontology highlight
ABSTRACT:
SUBMITTER: Chahwan R
PROVIDER: S-EPMC3637335 | biostudies-literature | 2013 Mar
REPOSITORIES: biostudies-literature
Chahwan Richard R Gravel Serge S Matsusaka Takahiro T Jackson Stephen P SP
Cell cycle (Georgetown, Tex.) 20130226 6
The budding yeast proteins Dma1 and Dma2 are members of the unique FHA-RING domain protein family and are linked to mitotic regulation and septin organization by ill-defined mechanisms. We show that Dma2 has ubiquitin ligase activity, and that septins Shs1 and Cdc11 are likely direct in vivo targets. We further propose that human RNF8, rather than Chfr, is the mammalian Dma homolog. As in yeast, RNF8 localizes to the centrosomes and cell division sites and promotes ubiquitylation of the septin S ...[more]