Dataset Information

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study.

ABSTRACT:

Objective

To evaluate if high-intensity interval training three times weekly for 12 weeks improves asthma control in overweight, postmenopausal women with uncontrolled, late-onset asthma.

Methods

The reported study is a randomized clinical pilot study (www.clinicaltrials.gov; NCT03747211) that compared 12 weeks of high-intensity interval training (spinning) with usual care. The five-question Asthma Control Questionnaire (ACQ-5) was used as primary outcome. Secondary measures included systemic inflammation and inflammation of the airways, body composition, and cardiac function during exercise.

Results

We included 12 women with asthma (mean age 65 years (SD 6); mean body mass index 30 kg/m² (SD 2)) from whom eight were randomized to exercise and four to control. Baseline ACQ-5 was 1.95 (SD 0.53) in the control group and 2.03 (0.54) in the exercise group. Patients had a mean blood eosinophil level of 0.16 × 10⁹cells/L (SD 0.07) and a mean fraction of exhaled nitric oxide of 23 ppb (SD 25). Mixed models showed that participants in the exercise group reduced their ACQ-5 by 0.55 points (95%CI -1.10 to -0.00; P = 0.08) compared with the control group. The exercise group significantly reduced their mean body fat percentage (-2.7%; 95%CI -4.5 to -0.8; P = 0.02), fat mass (-2.8 kg; 95%CI -5.1 to -0.4; P = 0.044) and android fat mass (-0.33 kg; 95%CI -0.60- -0.06; P = 0.038). In analyses of cardiac measures, we saw no significant effects on right ventricular function (fractional area change), diastolic function or left ventricular function.

Conclusions

Although changes in ACQ-5 were slightly insignificant, these preliminary findings indicate that aerobic exercise training can be used as a means to improve asthma control in overweight, postmenopausal women with asthma.

SUBMITTER: Hansen ESH

PROVIDER: S-EPMC10478610 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study.

Hansen Erik Sören Halvard ESH Rasmusen Hanne Kruuse HK Hostrup Morten M Hellsten Ylva Y Backer Vibeke V

European clinical respiratory journal 20230904 1

<h4>Objective</h4>To evaluate if high-intensity interval training three times weekly for 12 weeks improves asthma control in overweight, postmenopausal women with uncontrolled, late-onset asthma.<h4>Methods</h4>The reported study is a randomized clinical pilot study (www.clinicaltrials.gov; NCT03747211) that compared 12 weeks of high-intensity interval training (spinning) with usual care. The five-question Asthma Control Questionnaire (ACQ-5) was used as primary outcome. Secondary measures inclu ...[more]

PMID: 37674777

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Dataset Information

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study.

Objective

Methods

Results

Conclusions

Publications

The effect of aerobic exercise training on asthma control in postmenopausal women (ATOM): a randomized controlled pilot study.

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