Dataset Information

Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women.

ABSTRACT: Physical activity and diet are recommended lifestyle strategies to improve human health. Consequently, this study aimed to investigate the impact of aerobic exercise combined with dietary restriction on hormonal, metabolic, and psychological variables in postmenopausal women. Eligible 60 women were enrolled and assigned into two equal groups; the experimental group performed aerobic exercise three times per week for 12 weeks with diet restriction, and the control group only received the same diet program. Serum levels of sex hormones, insulin resistance, and depression scores were measured before and after the intervention.

Results

All measured variables were significantly changed in the experimental group compared to the control group (P = 0.001).

Conclusion

Changes in sex hormones are a biological marker of metabolic complications such as insulin resistance, which can be reduced with exercise and diet. In addition, they are effective therapeutic interventions in the treatment of mild depression.

Trial registration

Registration identifier number of this study is: NCT05136742 on https://register.ClinicalTrials.gov.

SUBMITTER: Elsayed MM

PROVIDER: S-EPMC8971591 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature

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Publications

Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women.

Elsayed Marwa M MM El Refaye Ghada E GE Rabiee Ahmed A Abouzeid Sameh S Elsisi Hany F HF

Heliyon 20220324 3

Physical activity and diet are recommended lifestyle strategies to improve human health. Consequently, this study aimed to investigate the impact of aerobic exercise combined with dietary restriction on hormonal, metabolic, and psychological variables in postmenopausal women. Eligible 60 women were enrolled and assigned into two equal groups; the experimental group performed aerobic exercise three times per week for 12 weeks with diet restriction, and the control group only received the same die ...[more]

PMID: 35368551

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Project description:IntroductionThis study investigates the effect of a modest weight loss either by a calorie restricted diet or mainly by increased physical exercise on health related quality of life (HRQoL) in overweight-to-obese and inactive postmenopausal women. We hypothesize that HRQoL improves with weight loss, and that exercise-induced weight loss is more effective for this than diet-induced weight loss.MethodsThe SHAPE-2 trial was primarily designed to evaluate any additional effect of weight loss by exercise compared with a comparable amount of weight loss by diet on biomarkers relevant for breast cancer risk. In the present analysis we focus on HRQoL. We randomly assigned 243 eligible women to a diet (n = 97), exercise (n = 98), or control group (n = 48). Both interventions aimed for 5-6 kg weight loss. HRQoL was measured at baseline and after 16 weeks by the SF-36 questionnaire.ResultsData of 214 women were available for analysis. Weight loss was 4.9 kg (6.1%) and 5.5 kg (6.9%) with diet and exercise, respectively. Scores of the SF-36 domain 'health change' increased significantly by 8.8 points (95% CI 1.6;16.1) with diet, and by 20.5 points (95% CI 13.2;27.7) with exercise when compared with control. Direct comparison of diet and exercise showed a statistically significantly stronger improvement with exercise. Both intervention groups showed a tendency towards improvements in most other domains, which were more pronounced in the exercise group, but not statistically different from control or each other.ConclusionIn a randomized trial in overweight-to-obese and inactive postmenopausal women a comparable 6%-7% weight loss was achieved by diet-only or mainly by exercise and showed improvements in physical and mental HRQoL domains, but results were not statistically significant in either the diet or exercise group. However, a modest weight loss does lead to a positive change in self-perceived health status. This effect was significantly larger with exercise-induced weight loss than with comparable diet-induced weight loss.Trial registrationClinicalTrials.gov NCT01511276.

Dataset Information

Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women.

Results

Conclusion

Trial registration

Publications

Aerobic exercise with diet induces hormonal, metabolic, and psychological changes in postmenopausal obese women.

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