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Strategy to combat biofilms: a focus on biofilm dispersal enzymes.

ABSTRACT: Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance (EPS), not only function as signaling networks, provide nutritional support, and facilitate surface adhesion, but also serve as a protective shield for the residing bacterial inhabitants against external stress, such as antibiotics, antimicrobials, and host immune responses. Biofilm-associated infections account for 65-80% of all human microbial infections that lead to serious mortality and morbidity. Tremendous effort has been spent to address the problem by developing biofilm-dispersing agents to discharge colonized microbial cells to a more vulnerable planktonic state. Here, we discuss the recent progress of enzymatic eradicating strategies against medical biofilms, with a focus on dispersal mechanisms. Particularly, we review three enzyme classes that have been extensively investigated, namely glycoside hydrolases, proteases, and deoxyribonucleases.

SUBMITTER: Wang S

PROVIDER: S-EPMC10485009 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Strategy to combat biofilms: a focus on biofilm dispersal enzymes.

Wang Shaochi S Zhao Yanteng Y Breslawec Alexandra P AP Liang Tingting T Deng Zhifen Z Kuperman Laura L LL Yu Qiuning Q

NPJ biofilms and microbiomes 20230907 1

Bacterial biofilms, which consist of three-dimensional extracellular polymeric substance (EPS), not only function as signaling networks, provide nutritional support, and facilitate surface adhesion, but also serve as a protective shield for the residing bacterial inhabitants against external stress, such as antibiotics, antimicrobials, and host immune responses. Biofilm-associated infections account for 65-80% of all human microbial infections that lead to serious mortality and morbidity. Tremen ...[more]

PMID: 37679355

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