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In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy.

ABSTRACT: As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/p _BAD -yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the use of biofilm dispersal to enhance antimicrobial efficacy in the treatment of biofilm-associated infections, representing a promising therapeutic strategy.

SUBMITTER: Roizman D

PROVIDER: S-EPMC5610510 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature

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In Vitro Evaluation of Biofilm Dispersal as a Therapeutic Strategy To Restore Antimicrobial Efficacy.

Roizman Dan D Vidaillac Celine C Givskov Michael M Yang Liang L

Antimicrobial agents and chemotherapy 20170922 10

As a proof-of-concept study, the direct impact of biofilm dispersal on the in vitro efficacy of imipenem and tobramycin was evaluated against 3-day-old biofilms of Pseudomonas aeruginosa Arabinose induction of biofilm dispersal via activation of the phosphodiesterase YhjH in the P. aeruginosa engineered strain PAO1/p BAD -yhjH resulted in increased antimicrobial efficacy and synergy of the imipenem-tobramycin combination. These results support the us ...[more]

PMID: 28760898

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