Ontology highlight
ABSTRACT:
SUBMITTER: Cetera M
PROVIDER: S-EPMC10499026 | biostudies-literature | 2023 Sep
REPOSITORIES: biostudies-literature
Cetera Maureen M Sharan Rishabh R Hayward-Lara Gabriela G Phillips Brooke B Biswas Abhishek A Halley Madalene M Beall Evalyn E vonHoldt Bridgett B Devenport Danelle D
Development (Cambridge, England) 20230907 17
The planar cell polarity (PCP) pathway collectively orients cells with respect to a body axis. Hair follicles of the murine epidermis provide a striking readout of PCP activity in their uniform alignment across the skin. Here, we characterize, from the molecular to tissue-scale, PCP establishment in the rosette fancy mouse, a natural variant with posterior-specific whorls in its fur, to understand how epidermal polarity is coordinated across the tissue. We find that rosette hair follicles emerge ...[more]