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Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices.

ABSTRACT: Small, single-layer microfluidic paper-based analytical devices (µPADs) offer potential for a range of point-of-care applications; however, they have been limited to low flow rates. Here, we investigate the role of laser cutting paper channels in maximizing flow rate in small profile devices with limited fluid volumes. We demonstrate that branching, laser-cut grooves can provide a 59.23-73.98% improvement in flow rate over a single cut, and a 435% increase over paper alone. These design considerations can be applied to more complex microfluidic devices with the aim of increasing the flow rate, and could be used in stand-alone channels for self-pumping.

Supplementary information

The online version contains supplementary material available at 10.1007/s10404-023-02679-8.

SUBMITTER: Macleod Briongos I

PROVIDER: S-EPMC10499984 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Maximizing flow rate in single paper layer, rapid flow microfluidic paper-based analytical devices.

Macleod Briongos Iain I Call Zachary D ZD Henry Charles S CS Bark David L DL

Microfluidics and nanofluidics 20230913 10

Small, single-layer microfluidic paper-based analytical devices (µPADs) offer potential for a range of point-of-care applications; however, they have been limited to low flow rates. Here, we investigate the role of laser cutting paper channels in maximizing flow rate in small profile devices with limited fluid volumes. We demonstrate that branching, laser-cut grooves can provide a 59.23-73.98% improvement in flow rate over a single cut, and a 435% increase over paper alone. These design consider ...[more]

PMID: 37719231

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