Ontology highlight
ABSTRACT:
SUBMITTER: Wright KM
PROVIDER: S-EPMC6821491 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Wright Kristina M KM Jhou Thomas C TC Pimpinelli Daniel D McDannald Michael A MA
eLife 20190930
The ventrolateral periaqueductal gray (vlPAG) is proposed to mediate fear responses to imminent danger. Previously we reported that vlPAG neurons showing short-latency increases in firing to a danger cue - the presumed neural substrate for fear output - signal threat probability in male rats (Wright et al., 2019). Here, we scrutinize the activity vlPAG neurons that <i>decrease</i> firing to danger. One cue-inhibited population flipped danger activity from early inhibition to late excitation: a p ...[more]