NO/redox disequilibrium in the failing heart and cardiovascular system.
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ABSTRACT:
SUBMITTER: Hare JM
PROVIDER: S-EPMC1052013 | biostudies-literature | 2005 Mar
REPOSITORIES: biostudies-literature
Publications
NO/redox disequilibrium in the failing heart and cardiovascular system.
Hare Joshua M JM Stamler Jonathan S JS
The Journal of clinical investigation 20050301 3
There is growing evidence that the altered production and/or spatiotemporal distribution of reactive oxygen and nitrogen species creates oxidative and/or nitrosative stresses in the failing heart and vascular tree, which contribute to the abnormal cardiac and vascular phenotypes that characterize the failing cardiovascular system. These derangements at the integrated system level can be interpreted at the cellular and molecular levels in terms of adverse effects on signaling elements in the hear ...[more]
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