Ontology highlight
ABSTRACT:
SUBMITTER: Miura S
PROVIDER: S-EPMC10524282 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Miura Shuhei S Habibabady Zahra A ZA Pollok Franziska F Ma Madelyn M Rosales Ivy A IA Kinoshita Kohei K Pratts Shannon S McGrath Gannon G Chaban Ryan R Fogarty Siobhan S Meibohm Bernd B Daugherty Bruce B Lederman Seth S Pierson Richard N RN
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20230407 8
Blockade of the CD40/CD154 T cell costimulation pathway is a promising approach to supplement or replace current clinical immunosuppression in solid organ transplantation. We evaluated the tolerability and activity of a novel humanized anti-CD154 monoclonal antibody, TNX-1500 (TNX), in a nonhuman primate heterotopic cardiac allogeneic (allo) transplant model. TNX-1500 contains a rupluzimab fragment antigen-binding region and an immunoglobin G4 crystallizable fragment region engineered to reduce ...[more]