Ontology highlight
ABSTRACT:
SUBMITTER: Kim SC
PROVIDER: S-EPMC5409881 | biostudies-literature | 2017 May
REPOSITORIES: biostudies-literature
Kim S C SC Wakwe W W Higginbotham L B LB Mathews D V DV Breeden C P CP Stephenson A C AC Jenkins J J Strobert E E Price K K Price L L Kuhn R R Wang H H Yamniuk A A Suchard S S Farris A B AB Pearson T C TC Larsen C P CP Ford M L ML Suri A A Nadler S S Adams A B AB
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20170225 5
The advent of costimulation blockade provides the prospect for targeted therapy with improved graft survival in transplant patients. Perhaps the most effective costimulation blockade in experimental models is the use of reagents to block the CD40/CD154 pathway. Unfortunately, successful clinical translation of anti-CD154 therapy has not been achieved. In an attempt to develop an agent that is as effective as previous CD154 blocking antibodies but lacks the risk of thromboembolism, we evaluated t ...[more]