Ontology highlight
ABSTRACT:
SUBMITTER: Lo DJ
PROVIDER: S-EPMC3558532 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Lo D J DJ Anderson D J DJ Weaver T A TA Leopardi F F Song M M Farris A B AB Strobert E A EA Jenkins J J Turgeon N A NA Mehta A K AK Larsen C P CP Kirk A D AD
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20130111 2
Belatacept is an inhibitor of CD28/B7 costimulation that is clinically indicated as a calcineurin inhibitor (CNI) alternative in combination with mycophenolate mofetil and steroids after renal transplantation. We sought to develop a clinically translatable, nonlymphocyte depleting, belatacept-based regimen that could obviate the need for both CNIs and steroids. Thus, based on murine data showing synergy between costimulation blockade and mTOR inhibition, we studied rhesus monkeys undergoing MHC- ...[more]