Ontology highlight
ABSTRACT:
SUBMITTER: Li S
PROVIDER: S-EPMC10528174 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Li Sha S Mereby Sarah A SA Rothstein Megan M Johnson Matthew R MR Brack Benjamin J BJ Mallarino Ricardo R
Cell reports 20230811 8
Rodents are taxonomically diverse and have evolved a variety of traits. A mechanistic understanding of such traits has remained elusive, however, largely because genome editing in non-traditional model species remains challenging. Here, using the African striped mouse (Rhabdomys pumilio), we describe TIGER (targeted in vivo genome editing in rodents), a method that relies on a simple intraoviductal injecting technique and uses recombinant adeno-associated viruses (rAAVs) as the sole vehicle to d ...[more]