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Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium Streptomyces sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells.

ABSTRACT: A HPLC-UV guided fractionation of the culture broth of Streptomyces sp. CNQ-617 has led to the isolation of a new quinazolinone derivative, actinoquinazolinone (1), as well as two known compounds, 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one (2) and 7-methoxy-8-hydroxy cycloanthranilylproline (3). The interpretation of 1D, 2D NMR, and MS spectroscopic data revealed the planar structure of 1. Furthermore, compound 1 suppressed invasion ability by inhibiting epithelial-mesenchymal transition markers (EMT) in AGS cells at a concentration of 5 µM. In addition, compound 1 decreased the expression of seventeen genes related to human cell motility and slightly suppressed the signal transducer and activator of the transcription 3 (STAT3) signal pathway in AGS cells. Together, these results demonstrate that 1 is a potent inhibitor of gastric cancer cells.

SUBMITTER: Pulat S 

PROVIDER: S-EPMC10532864 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature

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Actinoquinazolinone, a New Quinazolinone Derivative from a Marine Bacterium <i>Streptomyces</i> sp. CNQ-617, Suppresses the Motility of Gastric Cancer Cells.

Pulat Sultan S   Kim Da-Ae DA   Hillman Prima F PF   Oh Dong-Chan DC   Kim Hangun H   Nam Sang-Jip SJ   Fenical William W  

Marine drugs 20230913 9

A HPLC-UV guided fractionation of the culture broth of <i>Streptomyces</i> sp. CNQ-617 has led to the isolation of a new quinazolinone derivative, actinoquinazolinone (<b>1</b>), as well as two known compounds, 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one (<b>2</b>) and 7-methoxy-8-hydroxy cycloanthranilylproline (<b>3</b>). The interpretation of 1D, 2D NMR, and MS spectroscopic data revealed the planar structure of <b>1</b>. Furthermore, compound <b>1</b> suppressed invasion ability by inhib  ...[more]

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