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Saccharomonopyrones A-C, New ?-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490.

ABSTRACT: Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new ?-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first ?-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl and a 6-alkyl side-chain within a 3,4,5,6-tetrasubstituted ?-pyrone moiety. Saccharomonopyrone A exhibited weak antioxidant activity using a cation radical scavenging activity assay with an IC50 value of 140 ?M.

SUBMITTER: Yim CY

PROVIDER: S-EPMC5577594 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Saccharomonopyrones A-C, New α-Pyrones from a Marine Sediment-Derived Bacterium Saccharomonospora sp. CNQ-490.

Yim Chae-Yoon CY Le Tu Cam TC Lee Tae Gu TG Yang Inho I Choi Hansol H Lee Jusung J Kang Kyung-Yun KY Lee Jin Sil JS Lim Kyung-Min KM Yee Sung-Tae ST Kang Heonjoong H Nam Sang-Jip SJ Fenical William W

Marine drugs 20170803 8

Intensive study of the organic extract of the marine-derived bacterium Saccharomonospora sp. CNQ-490 has yielded three new α-pyrones, saccharomonopyrones A-C (1-3). The chemical structures of these compounds were assigned from the interpretation of 1D, 2D NMR and mass spectrometry data. Saccharomonopyrone A (1) is the first α-pyrone microbial natural product bearing the ethyl-butyl ether chain in the molecule, while saccharomonopyrones B and C possess unusual 3-methyl ...[more]

PMID: 28771166

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