Dataset Information

New thresholds in semi-quantitative [¹⁸F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

ABSTRACT:

Aim

[¹⁸F]FDG PET/CT proved accurate in the diagnostic work-up of large vessel vasculitis (LVV). While a visual interpretation is currently considered adequate, several attempts have been made to integrate it with a semiquantitative evaluation. In this regard, there is the need to validate current or new thresholds for the semiquantitative parameters on long-axial field of view (LAFOV) scanners.

Methods

We retrospectively evaluated 100 patients (50 with LVV and 50 controls) who underwent [¹⁸F]FDG LAFOV PET/CT. Semiquantitative parameters (SUVmax and SUVmean) were calculated for large vessels in 3 districts (supra-aortic [SA], thoracic aorta [TA], and infra-aortic [IA]). Values were also normalized to liver activity (SUV_max/L-SUV_max, and SUV_max/L-SUV_mean).

Results

Of the 50 patients diagnosed with LVV, SA vessels were affected in 38 (76%), TA in 42 (84%) and IA vessels in 26 (52%). To-liver normalized values had higher diagnostic accuracy than non-normalized values (AUC always ≥ 0.90 vs. 0.74-0.89). For the SA vessels, best thresholds were 0.66 for SUV_max/L-SUV_max and 0.88 for SUV_max/L-SUV_mean; for the TA, 1.0 for SUV_max/L-SUV_max and 1.30 for SUV_max/L-SUV_mean; finally, for IA vessels, the best threshold was 0.83 for SUV_max/L-SUV_max and 1.11 for SUV_max/L-SUV_mean.

Conclusion

LAFOV [¹⁸F]FDG-PET/CT is accurate in the diagnostic workup of LVV, but different threshold in semi-quantitative parameters than reported in literature for standard scanners should be considered.

SUBMITTER: Knappe L

PROVIDER: S-EPMC10611821 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature

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Publications

New thresholds in semi-quantitative [<sup>18</sup>F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

Knappe Luisa L Bregenzer Carola C Gözlügöl Nasir N Mingels Clemens C Alberts Ian I Rominger Axel A Caobelli Federico F

European journal of nuclear medicine and molecular imaging 20230907 13

<h4>Aim</h4>[<sup>18</sup>F]FDG PET/CT proved accurate in the diagnostic work-up of large vessel vasculitis (LVV). While a visual interpretation is currently considered adequate, several attempts have been made to integrate it with a semiquantitative evaluation. In this regard, there is the need to validate current or new thresholds for the semiquantitative parameters on long-axial field of view (LAFOV) scanners.<h4>Methods</h4>We retrospectively evaluated 100 patients (50 with LVV and 50 contro ...[more]

PMID: 37676501

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Dataset Information

New thresholds in semi-quantitative [¹⁸F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

Aim

Methods

Results

Conclusion

Publications

New thresholds in semi-quantitative [<sup>18</sup>F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

Dataset Information

New thresholds in semi-quantitative [18F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

Aim

Methods

Results

Conclusion

Publications

New thresholds in semi-quantitative [<sup>18</sup>F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets

New thresholds in semi-quantitative [¹⁸F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.