Atomically precise ultrasmall copper cluster for room-temperature highly regioselective dehydrogenative coupling.

ABSTRACT: Three-component dehydrogenative coupling reactions represent important and practical methodologies for forging new C-N bonds and C-C bonds. Achieving highly all-in-one dehydrogenative coupling functionalization by a single catalytic system remains a great challenge. Herein, we develop a rigid-flexible-coupled copper cluster [Cu₃(NHC)₃(PF₆)₃] (Cu₃NC^(NHC)) using a tridentate N-heterocyclic carbene ligand. The shell ligand endows Cu₃NC^(NHC) with dual attributes, including rigidity and flexibility, to improve activity and stability. The Cu₃NC^(NHC) is applied to catalyze both highly all-in-one dehydrogenative coupling transformations. Mechanistic studies and density functional theory illustrate that the improved regioselectivity is derived from the low energy of ion pair with copper acetylide and endo-iminium ions and the low transition state, which originates from the unique physicochemical properties of the Cu₃NC^(NHC) catalyst. This work highlights the importance of N-heterocyclic carbene in the modification of copper clusters, providing a new design rule to protect cluster catalytic centers and enhance catalysis.

SUBMITTER: Jia T 

PROVIDER: S-EPMC10613312 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature