Unknown

Dataset Information

0

Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling.


ABSTRACT: A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1-4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes.

SUBMITTER: Senecal TD 

PROVIDER: S-EPMC3093444 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature

altmetric image

Publications

Room temperature aryl trifluoromethylation via copper-mediated oxidative cross-coupling.

Senecal Todd D TD   Parsons Andrew T AT   Buchwald Stephen L SL  

The Journal of organic chemistry 20110114 4


A method for the room temperature copper-mediated trifluoromethylation of aryl and heteroaryl boronic acids has been developed. This protocol is amenable to normal benchtop setup and reactions typically require only 1-4 h. Proceeding under mild conditions, the method tolerates a range of functional groups, allowing access to a variety of trifluoromethylarenes. ...[more]

Similar Datasets

| S-EPMC3096486 | biostudies-literature
| S-EPMC4019426 | biostudies-literature
| S-EPMC5201211 | biostudies-literature
| S-EPMC2531206 | biostudies-literature
| S-EPMC10613312 | biostudies-literature
| S-EPMC6296300 | biostudies-literature
| S-EPMC3454444 | biostudies-literature
| S-EPMC4924930 | biostudies-literature
| S-EPMC8150100 | biostudies-literature
| S-EPMC6222728 | biostudies-literature