Ontology highlight
ABSTRACT:
SUBMITTER: Chong JA
PROVIDER: S-EPMC1061635 | biostudies-literature | 2005 Apr
REPOSITORIES: biostudies-literature
Chong Jayhong A JA Moran Magdalene M MM Teichmann Martin M Kaczmarek J Stefan JS Roeder Robert R Clapham David E DE
Molecular and cellular biology 20050401 7
The lack of direct targets for TATA-binding protein (TBP)-like factors (TLFs) confounds the understanding of their role in gene expression. Here we report that human TLF (also called TBP-related factor 2 [TRF2]) activates a number of different genes, including the neurofibromatosis type 1 (NF1) gene. The overexpression of TLF increases the amount of NF1 mRNA in cells. In vivo, TLF binds to and upregulates transcription from a fragment of the NF1 promoter. In vitro, purified TLF-TFIIA binds direc ...[more]