Ontology highlight
ABSTRACT:
SUBMITTER: Adler N
PROVIDER: S-EPMC10624356 | biostudies-literature | 2023 Nov
REPOSITORIES: biostudies-literature
Adler Nina N Bahcheli Alexander T AT Cheng Kevin C L KCL Al-Zahrani Khalid N KN Slobodyanyuk Mykhaylo M Pellegrina Diogo D Schramek Daniel D Reimand Jüri J
Science advances 20231103 44
Mutational signatures represent a genomic footprint of endogenous and exogenous mutational processes through tumor evolution. However, their functional impact on the proteome remains incompletely understood. We analyzed the protein-coding impact of single-base substitution (SBS) signatures in 12,341 cancer genomes from 18 cancer types. Stop-gain mutations (SGMs) (i.e., nonsense mutations) were strongly enriched in SBS signatures of tobacco smoking, APOBEC cytidine deaminases, and reactive oxygen ...[more]