Ontology highlight
ABSTRACT:
SUBMITTER: Mopuri R
PROVIDER: S-EPMC10627474 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
Mopuri Rohini R Welbourn Sarah S Charles Tysheena T Ralli-Jain Pooja P Rosales David D Burton Samantha S Aftab Areeb A Karunakaran Kirti K Pellegrini Kathryn K Kilembe William W Karita Etienne E Gnanakaran Sandrasegaram S Upadhyay Amit A AA Bosinger Steven E SE Derdeyn Cynthia A CA
PLoS pathogens 20231025 10
A protective HIV-1 vaccine has been hampered by a limited understanding of how B cells acquire neutralizing activity. Our previous vaccines expressing two different HIV-1 envelopes elicited robust antigen specific serum IgG titers in 20 rhesus macaques; yet serum from only two animals neutralized the autologous virus. Here, we used high throughput immunoglobulin receptor and single cell RNA sequencing to characterize the overall expansion, recall, and maturation of antigen specific B cells longi ...[more]