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Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.

ABSTRACT: A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes.

SUBMITTER: Kharel MK

PROVIDER: S-EPMC2895501 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Enzymatic total synthesis of rabelomycin, an angucycline group antibiotic.

Kharel Madan Kumar MK Pahari Pallab P Lian Hui H Rohr Jürgen J

Organic letters 20100601 12

A one-pot enzymatic total synthesis of angucycline antibiotic rabelomycin was accomplished, starting from acetyl-CoA and malonyl-CoA, using a mixture of polyketide synthase (PKS) enzymes of the gilvocarcin, ravidomycin, and jadomycin biosynthetic pathways. The in vitro results were compared to in vivo catalysis using analogous sets of enzymes. ...[more]

PMID: 20486694

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