Ontology highlight
ABSTRACT:
SUBMITTER: Yamashiro S
PROVIDER: S-EPMC10733299 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Yamashiro Sawako S Rutkowski David M DM Lynch Kelli Ann KA Liu Ying Y Vavylonis Dimitrios D Watanabe Naoki N
Nature communications 20231220 1
Force transmission at integrin-based adhesions is important for cell migration and mechanosensing. Talin is an essential focal adhesion (FA) protein that links F-actin to integrins. F-actin constantly moves on FAs, yet how Talin simultaneously maintains the connection to F-actin and transmits forces to integrins remains unclear. Here we show a critical role of dynamic Talin unfolding in force transmission. Using single-molecule speckle microscopy, we found that the majority of Talin are bound on ...[more]