Ontology highlight
ABSTRACT:
SUBMITTER: Valdez V
PROVIDER: S-EPMC10769297 | biostudies-literature | 2023 Dec
REPOSITORIES: biostudies-literature
Valdez Venecia V Ma Meisheng M Gouveia Bernardo B Zhang Rui R Petry Sabine S
bioRxiv : the preprint server for biology 20231218
In large vertebrate spindles, the majority of microtubules are formed via branching microtubule nucleation, whereby microtubules nucleate along the side of pre-existing microtubules. Hepatoma up-regulated protein (HURP) is a microtubule-associated protein that has been implicated in spindle assembly, but its mode of action is yet to be defined. In this study, we show that HURP is necessary for RanGTP-induced branching microtubule nucleation in <i>Xenopus</i> egg extract. Specifically, HURP stabi ...[more]