Ontology highlight
ABSTRACT:
SUBMITTER: Glotzer M
PROVIDER: S-EPMC2789570 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Nature reviews. Molecular cell biology 20090101 1
During metaphase, sister chromatids are positioned at the midpoint of the microtubule-based mitotic spindle in preparation for their segregation. The onset of anaphase triggers inactivation of the key mitotic kinase cyclin-dependent kinase 1 (CDK1) and the polewards movement of sister chromatids. During anaphase, the mitotic spindle reorganizes in preparation for cytokinesis. Kinesin motor proteins and microtubule-associated proteins bundle the plus ends of interpolar microtubules and generate t ...[more]