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High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens.

ABSTRACT: We analyzed the reverse transcriptase genotypes of human immunodeficiency virus type 1 subtype C viruses isolated from 23 patients in Botswana treated with didanosine-based regimens. The K65R mutation was selected either alone or together with the Q151M, S68G, or F116Y substitution in viruses from seven such individuals. The results of in vitro passage experiments were consistent with an apparent increased propensity of subtype C viruses to develop the K65R substitution.

SUBMITTER: Doualla-Bell F 

PROVIDER: S-EPMC1693987 | biostudies-literature | 2006 Dec

REPOSITORIES: biostudies-literature

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High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens.

Doualla-Bell Florence F   Avalos Ava A   Brenner Bluma B   Gaolathe Tendani T   Mine Madisa M   Gaseitsiwe Simani S   Oliveira Maureen M   Moisi Daniella D   Ndwapi Ndwapi N   Moffat Howard H   Essex Max M   Wainberg Mark A MA  

Antimicrobial agents and chemotherapy 20061002 12

We analyzed the reverse transcriptase genotypes of human immunodeficiency virus type 1 subtype C viruses isolated from 23 patients in Botswana treated with didanosine-based regimens. The K65R mutation was selected either alone or together with the Q151M, S68G, or F116Y substitution in viruses from seven such individuals. The results of in vitro passage experiments were consistent with an apparent increased propensity of subtype C viruses to develop the K65R substitution. ...[more]

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