Ontology highlight
ABSTRACT:
SUBMITTER: Jiang Y
PROVIDER: S-EPMC10816394 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Jiang Yuhao Y Han Peiwen P Yin Guangxing G Wang Qianna Q Feng Junhong J Ruan Qing Q Xiao Di D Zhang Junbo J
International journal of molecular sciences 20240115 2
To develop a novel <sup>99m</sup>Tc-labeled ubiquicidin 29-41 derivative for bacterial infection single-photon emission computed tomography (SPECT) imaging with improved target-to-nontarget ratio and lower nontarget organ uptake, a series of isocyanide ubiquicidin 29-41 derivatives (CNnUBI 29-41, <i>n</i> = 5-9) with different carbon linkers were designed, synthesized and radiolabeled with the [<sup>99m</sup>Tc]Tc(I)<sup>+</sup> core, [<sup>99m</sup>Tc][Tc(I)(CO)<sub>3</sub>(H<sub>2</sub>O)<sub> ...[more]