Ontology highlight
ABSTRACT:
SUBMITTER: Khor AHP
PROVIDER: S-EPMC10823282 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Khor Amy Hui Ping AHP Koguchi Tomoyuki T Liu Hao H Kakuta Masanori M Matsubara Daisuke D Wen Ruimeng R Sagiya Yoji Y Imoto Seiya S Nakagawa Hidewaki H Matsuda Koichi K Tanikawa Chizu C
Cancer science 20231204 1
p53 is a key tumor suppressor mutated in half of human cancers. In recent years, p53 was shown to regulate a wide variety of functions. From the transcriptome analysis of 24 tissues of irradiated mice, we identified 553 genes markedly induced by p53. Gene Ontology (GO) enrichment analysis found that the most associated biological process was innate immunity. 16S rRNA-seq analysis revealed that Akkermansia, which has anti-inflammatory properties and is involved in the regulation of intestinal bar ...[more]