Ontology highlight
ABSTRACT:
SUBMITTER: Gurusaran M
PROVIDER: S-EPMC10827754 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Gurusaran Manickam M Erlandsen Benedikte S BS Davies Owen R OR
Communications biology 20240130 1
The LINC complex transmits cytoskeletal forces into the nucleus to control the structure and movement of nuclear contents. It is formed of nuclear SUN and cytoplasmic KASH proteins, which interact within the nuclear lumen, immediately below the outer nuclear membrane. However, the symmetrical location of KASH molecules within SUN-KASH complexes in previous crystal structures has been difficult to reconcile with the steric requirements for insertion of their immediately upstream transmembrane hel ...[more]