Ontology highlight
ABSTRACT:
SUBMITTER: Sutro JL
PROVIDER: S-EPMC10835656 | biostudies-literature | 2024 Jan
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20240119 4
Archangiumide is the first known macrolide natural product comprising an endocyclic allene. For the ring strain that this linear substructure might entail, it was planned to unveil the allene at a very late stage of the projected total synthesis; in actual fact, this was achieved as the last step of the longest linear sequence by using an otherwise globally deprotected substrate. This unconventional timing was made possible by a gold catalyzed rearrangement of a macrocyclic propargyl benzyl ethe ...[more]